Stacks / Weight & Metabolic Health
The Weight & Metabolic Program
The complete body-recomposition protocol — a GLP-1 anchor with the metabolic foundation around it, the fat-specific layer, and the muscle-protecting optimal build.
The GLP-1 era made serious weight loss achievable — and created a new problem: people run the injection alone, lose muscle along with fat, and end up smaller but not better. This program treats the GLP-1 as the anchor of a system: the metabolic foundation around it, the fat-specific accelerants, and the layer that protects the muscle you keep.
The Foundation — the anchor plus the base
- Your GLP-1 anchor — pick ONE: Tirzepatide (the proven dual agonist, ~15–21% trial loss), Semaglutide (the longest track record, gentlest entry), or Retatrutide (the frontier triple, the biggest numbers). Whichever you choose: start low, titrate monthly, never rush the ladder.
- MOTS-c — 2.5 mg, 3× weekly. Insulin sensitivity and energy expenditure — the "exercise in a vial" leg that keeps metabolism up while calories are down.
- NAD+ — 100 mg daily. Calorie deficits drain energy; this is the cellular floor that keeps training quality up through the cut.
The Fat-Specific Layer
- AOD-9604 — 400 mcg fasted mornings. The GH fat-fragment: lipolysis without appetite effects — stacks cleanly under a GLP-1.
- 5-Amino-1MQ — 100 mg daily, oral. Blocks the metabolic parking brake in fat tissue; the needle-free furnace leg.
- Tesamorelin — 1.5 mg daily. The visceral-fat specialist — trial-proven against the dangerous deep belly fat specifically.
The Complete Optimal Build — protect what matters
- CJC-1295 + Ipamorelin (blend) — 200 mcg pre-bed. The muscle-preservation leg: GH pulse for lean-mass retention and recovery while cutting. Pairs with the non-negotiables — protein and resistance training.
- Glutathione — 400 mg, 3× weekly. Rapid fat loss releases stored oxidative load; this handles the exhaust.
- Cagrilintide — the advanced pairing. The amylin analog designed to combine with semaglutide (the CagriSema trials: ~21–23% loss). For experienced runners taking the next step.
The full program at a glance
| Layer | Compound | How it's run |
|---|---|---|
| Foundation | GLP-1 anchor (pick one) | weekly, slow titration |
| Foundation | MOTS-c | 2.5 mg 3×/week |
| Foundation | NAD+ | 100 mg daily |
| Fat layer | AOD-9604 | 400 mcg fasted AM |
| Fat layer | 5-Amino-1MQ | 100 mg daily (caps) |
| Fat layer | Tesamorelin | 1.5 mg daily |
| Optimal | CJC-1295/Ipamorelin blend | 200 mcg pre-bed |
| Optimal | Glutathione | 400 mg 3×/week |
| Optimal | Cagrilintide | weekly (advanced pairing) |
Track more than the scale — waist, strength numbers, photos. The Supply Builder sizes the whole program for a full titration run so you're never mid-ladder waiting on a reorder.
For the women reading this
You're not the exception in this category — you're the majority: GLP-1 users skew female, and the trials were run on majority-women cohorts. Same compounds, same titration ladders, Standard tier. The Women's Program pairs the weight anchor with the skin and energy layers.
Research protocols, not a prescription — talk to a physician before touching anything.
Compounds in this program
Tirzepatide
The proven dual GLP-1/GIP agonist — an approved medication class with ~20% trial weight loss, studied in research form for metabolic health.
Retatrutide
The next-generation weight compound — a triple agonist (GLP-1 + GIP + glucagon) that posted the largest weight-loss numbers ever seen in trials. Still in phase 3.
Semaglutide
The peptide that changed the conversation — the original blockbuster GLP-1 agonist, with the deepest human trial record of any compound on this site.
MOTS-c
The "exercise in a vial" research peptide — encoded in mitochondrial DNA, studied for insulin sensitivity, endurance, and metabolic flexibility.
NAD+
Not technically a peptide — the cellular energy coenzyme itself, injected to restore levels that fall ~50% between youth and middle age. The longevity-circuit staple.
AOD-9604
The fat-loss fragment — the tail end of growth hormone that keeps the fat-burning signal and drops everything else. No appetite suppression, no GLP-1 stomach.
5-Amino-1MQ
The oral metabolism molecule — a small NNMT inhibitor studied for raising cellular NAD+ and re-firing stubborn fat metabolism. Capsules, not needles.
Tesamorelin
The most clinically proven GHRH analog — an FDA-approved drug (for HIV-related belly fat) that research circles study for visceral fat specifically.
CJC-1295 (no DAC)
A growth-hormone-releasing-hormone analog that prompts your pituitary to release its own GH in natural pulses — almost always paired with Ipamorelin.
Ipamorelin
The cleanest of the GH secretagogues — triggers a growth-hormone pulse without meaningfully raising hunger or cortisol. CJC-1295's standard partner.
Glutathione
The body's own master antioxidant — a tripeptide on every IV-therapy and med-spa menu, studied for detoxification, recovery, and oxidative stress.
Cagrilintide
The next weight-loss mechanism — an amylin analog that creates satiety through a completely different pathway than GLP-1, designed to pair with semaglutide.