Peptide Library / Weight & Metabolic
AOD-9604
Also known as: Anti-Obesity Drug 9604 (GH fragment 176-191)
The fat-loss fragment — the tail end of growth hormone that keeps the fat-burning signal and drops everything else. No appetite suppression, no GLP-1 stomach.
| Typical research dose | 300–500 mcg |
|---|---|
| Frequency | 1× daily, fasted morning |
| Route | Subcutaneous injection |
| Cycle length | 8–12 weeks |
Figures reflect protocols commonly reported in the research community — not a prescription or a recommendation.
What it is
AOD-9604 is amino acids 176–191 of human growth hormone — the specific region responsible for GH's fat-metabolism effects, isolated from the parts that raise IGF-1, affect blood sugar, or grow tissue. It went through actual human obesity trials in the 2000s (it was developed as a pharmaceutical), showed modest fat loss with a clean safety profile, and holds US GRAS status as an ingredient — an unusually documented history for a research compound.
What the research looks at
- Fat metabolism — stimulates lipolysis (fat breakdown) and inhibits lipogenesis (fat creation) in animal and human studies, without GH's systemic effects.
- Human trials — six-month obesity trials showed statistically significant but modest weight loss vs placebo, with placebo-level side effects.
- Cartilage repair — a second research lane: intra-articular studies in osteoarthritis models, sometimes paired with hyaluronic acid.
- No IGF-1 elevation — the differentiator: metabolic effect without the growth-axis cautions.
How protocols are commonly structured
300–500 mcg subcutaneous, fasted, first thing in the morning (fat oxidation is the goal, so it's kept away from food and often paired with fasted cardio), for 8–12 weeks. Honest framing: its effect is a lever, not a truck — the GLP-1 class (semaglutide, tirzepatide) moves more weight; AOD-9604 is chosen when appetite suppression isn't wanted — fighters managing weight while keeping training fuel, or layering onto an already-dialed diet.
Reconstitution & storage
Lyophilized powder; bacteriostatic-water reconstitution (calculator), refrigerate after mixing.
Research protocols, not a prescription — talk to a physician before touching anything.