Peptide Library / Energy & Longevity
NAD+
Also known as: Nicotinamide adenine dinucleotide
Not technically a peptide — the cellular energy coenzyme itself, injected to restore levels that fall ~50% between youth and middle age. The longevity-circuit staple.
| Typical research dose | 50–100 mg daily or 250–500 mg 1–2× weekly |
|---|---|
| Frequency | Daily (small) or weekly (larger) |
| Route | Subcutaneous injection (slow); IV in clinic settings |
| Cycle length | 4–12 weeks or ongoing maintenance |
Figures reflect protocols commonly reported in the research community — not a prescription or a recommendation.
What it is
NAD+ is a coenzyme present in every living cell — it shuttles electrons in the reactions that turn food into ATP, and it's the fuel for sirtuins and PARPs, the enzyme families most associated with DNA repair and aging biology. Levels decline roughly by half from young adulthood to middle age, which is the entire premise of NAD+ restoration protocols.
What the research looks at
- Cellular energy & fatigue — the most commonly reported subjective effect of restoration protocols.
- DNA repair & sirtuin activity — the longevity-mechanism literature is large, mostly animal and in-vitro.
- Addiction & neurology clinics — IV NAD+ has a long clinical-use history for withdrawal support and brain fog, though controlled-trial support is thin.
- What's missing — robust human outcome trials for injected NAD+ specifically; most human data is on oral precursors (NR, NMN).
How protocols are commonly structured
Two common shapes: small daily subcutaneous doses (50–100 mg) or larger weekly-ish doses (250–500 mg). The defining practical note: inject slowly — NAD+ pushed fast produces a very unpleasant (harmless, but memorable) wave of chest tightness and nausea. Splitting and slowing eliminates most of it.
Reconstitution & storage
Often supplied pre-dissolved or as powder in large-mg vials (500–1000 mg). Refrigerate; protect from light. Doses here are in mg and large — draw volumes are bigger than peptide draws, another reason to go slow.
Research protocols, not a prescription — talk to a physician before touching anything.