Peptide Library / Weight & Metabolic
Cagrilintide
Also known as: The amylin half of "CagriSema"
The next weight-loss mechanism — an amylin analog that creates satiety through a completely different pathway than GLP-1, designed to pair with semaglutide.
| Typical research dose | 0.25–0.5 mg/week to start; trial range up to 4.5 mg/week |
|---|---|
| Frequency | 1× weekly |
| Route | Subcutaneous injection |
| Cycle length | Ongoing with titration; not a short cycle |
Figures reflect protocols commonly reported in the research community — not a prescription or a recommendation.
What it is
Cagrilintide is a long-acting analog of amylin — the hormone your pancreas releases alongside insulin that tells your brain "meal registered, stop eating." It's Novo Nordisk's designed partner for semaglutide: the combination (CagriSema) is in late-stage trials on the thesis that hitting satiety through two different pathways beats pushing one pathway harder.
What the research looks at
- Weight loss, solo — phase 2: ~10–12% body-weight loss at the top dose alone — competitive with GLP-1 monotherapy.
- Weight loss, combined — CagriSema phase 3 (REDEFINE): ~21–23% average loss, among the largest ever recorded, with many reporting easier tolerability than equivalent GLP-1-only dosing.
- Meal mechanics — amylin slows gastric emptying and works meal-by-meal satiety rather than all-day appetite suppression — users describe it as "meals just end sooner."
- What's missing — approval anywhere; like retatrutide, this is an in-trial pharmaceutical.
How protocols are commonly structured
Trial design is the template: start 0.25–0.5 mg once weekly, titrate every 4 weeks as tolerated (trial range ran to 4.5 mg). In combination protocols it's dosed the same day as the GLP-1 partner. The class rules carry over: slow ladder, protein, resistance training, track more than the scale — and the standing medullary-thyroid-history exclusion that applies across this whole category.
Reconstitution & storage
Lyophilized powder; bacteriostatic-water reconstitution (calculator), weekly mg dosing, refrigerate after mixing.
Research protocols, not a prescription — talk to a physician before touching anything.