Stacks / Over 40
The Over-40 Program
The complete "feel like I used to" protocol — rebuild the hormonal and cellular foundation age erodes, add the over-40 specific layer, and finish with the full optimization build.
Three systems decline together after 40 — the growth-hormone pulse (down more than half from your 20s), cellular NAD+ (roughly halved by middle age), and recovery speed. Most men attack one symptom at a time; this program rebuilds the whole floor first, then adds the over-40-specific layer, then the complete optimization build for men who want the entire system running.
The Foundation — everyone starts here
- CJC-1295 + Ipamorelin (combined blend vial) — 200 mcg pre-bed, fasted. The core move: restore the nightly GH pulse you had at 25 — deeper sleep first, then recovery, then body composition. (Sermorelin is the clinic-classic alternative for this slot.)
- NAD+ — 100 mg daily, slow. The cellular energy floor — steadier energy and clearer head are the commonly reported first effects.
- BPC-157 + TB-500 (blend vial) — 500 mcg daily. The joints and tendons that complain after every workout are connective-tissue problems; this is the repair base.
The Over-40 Layer
- MOTS-c — 2.5 mg, 3× weekly. The exercise-mimetic: insulin sensitivity and endurance — the metabolic flexibility that quietly disappeared in your 30s.
- DSIP — 200 mcg pre-bed. Deep sleep is where the GH leg pays out; DSIP deepens exactly that stage.
- Epithalon — one 15-day course (10 mg/day), twice a year. The longevity leg: telomere research plus normalized melatonin output.
The Complete Optimal Build
- PT-141 — 1 mg as needed. The drive compound — works on desire circuitry, not plumbing.
- Tesamorelin — 1.5 mg daily. The visceral-fat specialist — the deep belly fat that resists everything else is its exact trial-proven target.
- Glutathione — 400 mg, 3× weekly. The master antioxidant, pairing with NAD+ (engine and exhaust).
- 5-Amino-1MQ — 100 mg daily, oral. The needle-free metabolic leg — keeps the furnace hot.
The full program at a glance
| Layer | Compound | How it's run |
|---|---|---|
| Foundation | CJC-1295/Ipamorelin blend | 200 mcg pre-bed |
| Foundation | NAD+ | 100 mg daily |
| Foundation | BPC-157/TB-500 blend | 500 mcg daily |
| Over-40 | MOTS-c | 2.5 mg 3×/week |
| Over-40 | DSIP | 200 mcg pre-bed |
| Over-40 | Epithalon | 15-day course, 2×/year |
| Optimal | PT-141 | 1 mg as needed |
| Optimal | Tesamorelin | 1.5 mg daily |
| Optimal | Glutathione | 400 mg 3×/week |
| Optimal | 5-Amino-1MQ | 100 mg daily (caps) |
The GH pair works on a months timescale — commit to 12 weeks minimum before judging. The Supply Builder sizes the whole program vial-by-vial for the duration you choose.
For the women reading this
Everything here applies over-40 women identically — the GH pulse, NAD+, and recovery declines are the same biology. Run Standard tier, and swap PT-141 guidance for its women's-approved framing (it's literally a female medication first). The Women's Program reshuffles these same pieces skin-and-energy-first.
Research protocols, not a prescription — talk to a physician before touching anything.
Compounds in this program
CJC-1295 (no DAC)
A growth-hormone-releasing-hormone analog that prompts your pituitary to release its own GH in natural pulses — almost always paired with Ipamorelin.
Ipamorelin
The cleanest of the GH secretagogues — triggers a growth-hormone pulse without meaningfully raising hunger or cortisol. CJC-1295's standard partner.
NAD+
Not technically a peptide — the cellular energy coenzyme itself, injected to restore levels that fall ~50% between youth and middle age. The longevity-circuit staple.
BPC-157
The most-discussed recovery peptide — studied for tendon, ligament, muscle, and gut repair. The usual first compound for anyone training hard with nagging injuries.
TB-500
BPC-157's usual partner — studied for flexibility, tissue repair, and reducing inflammation across the whole body rather than one site.
MOTS-c
The "exercise in a vial" research peptide — encoded in mitochondrial DNA, studied for insulin sensitivity, endurance, and metabolic flexibility.
DSIP
The sleep peptide — studied since the 1970s for deepening slow-wave sleep, which is where every other kind of recovery actually happens.
Epithalon
The telomere peptide — a four-amino-acid compound from Russian longevity research, studied for telomerase activation and sleep-hormone normalization.
PT-141
The libido peptide — works through the nervous system rather than blood flow, which is exactly why it's studied where the little blue pill does nothing.
Tesamorelin
The most clinically proven GHRH analog — an FDA-approved drug (for HIV-related belly fat) that research circles study for visceral fat specifically.
Glutathione
The body's own master antioxidant — a tripeptide on every IV-therapy and med-spa menu, studied for detoxification, recovery, and oxidative stress.
5-Amino-1MQ
The oral metabolism molecule — a small NNMT inhibitor studied for raising cellular NAD+ and re-firing stubborn fat metabolism. Capsules, not needles.