Peptide Library / Growth Hormone Axis
Sermorelin
Also known as: GRF 1-29
The clinic-standard growth-hormone peptide — the first 29 amino acids of natural GHRH, with decades of prescription history behind it.
| Typical research dose | 200–500 mcg |
|---|---|
| Frequency | 1× daily (pre-bed, fasted) |
| Route | Subcutaneous injection |
| Cycle length | 3–6 months (effects build slowly) |
Figures reflect protocols commonly reported in the research community — not a prescription or a recommendation.
What it is
Sermorelin is the shortest fully-active fragment of your natural growth-hormone- releasing hormone — and the elder statesman of the GH-peptide family. It was an FDA-approved pediatric medication (Geref) for years and remains the compound age-management and TRT clinics reach for first when restoring adult GH pulse, because prescribers know it. CJC-1295 no DAC is essentially sermorelin's modified, longer-acting descendant.
What the research looks at
- GH and IGF-1 restoration — reliable elevation of natural pulsatile GH release.
- Sleep quality — reinforces the deep-sleep GH pulse; consistently the first effect people report.
- Body composition — gradual fat reduction and lean-mass support over months.
- Clinical familiarity — its long prescription history is itself a data point: side-effect profile is well characterized and mild.
How protocols are commonly structured
200–500 mcg subcutaneous, once daily before bed, fasted — the classic clinic protocol, run for 3–6 months. It's gentler per-mcg than the CJC+Ipamorelin pair; many treat sermorelin as the on-ramp and the pair as the upgrade. Expect a months-scale timeline: sleep first, body composition later.
Reconstitution & storage
Lyophilized powder; bacteriostatic-water reconstitution (calculator), refrigerate after mixing, ~4 weeks.
Research protocols, not a prescription — talk to a physician before touching anything.