Stacks / Women's Health

The Perimenopause Program

The complete transition-years protocol — rebuild the sleep and energy floor the hormonal shift erodes, work the body-composition and skin changes directly, and run the full resilience build.

Somewhere in the 40s the rules change without notice: sleep fractures, the midsection stops responding to what always worked, skin thins, mood runs hotter, drive runs colder. Most of the advice women get for this decade is "that's normal" — technically true, completely useless. This program is the peptide world's answer to the transition years, built on the same three-layer logic as everything on this site — and it runs alongside (never instead of) whatever you and your physician decide about HRT.

The Foundation — rebuild the floor first

• CJC-1295 + Ipamorelin (blend) — 200 mcg pre-bed, fasted. The GH pulse declines in parallel with the hormonal shift and drives the same complaints — sleep depth, recovery, body composition, skin thickness. Restoring it is the single highest-leverage move of this decade.
• NAD+ — 100 mg daily, slow. The running-on-fumes feeling has a cellular-energy floor under it; levels have roughly halved by now, and this is the direct fix.
• DSIP — 200 mcg pre-bed. Perimenopausal sleep fragmentation is the hallmark symptom — and the multiplier: every other system on this page runs through the night shift.

The Transition Layer

• Semaglutide — titrating weekly from 0.25 mg. The midsection shift is metabolic, not moral — estrogen decline changes fat distribution and insulin sensitivity, and the entry GLP-1 (with the deepest women's trial record in the class) is the modern tool for exactly that. Full picture: Choosing Your GLP-1.
• Glow Blend (GHK-Cu/BPC/TB) — 2 mg daily. Collagen production drops fast across the transition; the copper-peptide literature — built overwhelmingly on women's skin — is the direct response.
• Selank — 300 mcg daily (or nasal). The anxiety that arrives uninvited in these years is neurochemical, not a character change — calm without sedation, and no benzodiazepine story.

The Complete Optimal Build

• Glutathione — 400 mg, 3× weekly. The antioxidant floor, with its own brightening literature.
• Epithalon — one 15-day course, 1–2× a year. The circadian-and-longevity reset layer — pineal melatonin output declines exactly when sleep can least afford it.
• PT-141 — 0.5–1 mg as needed. Drive changes are part of this decade's package; this is literally an FDA-approved women's medication for low desire, run at the women's end of the range.

The full program at a glance

Run Standard tier throughout, commit 12 weeks before judging the GH-axis leg, and track sleep first — it moves earliest and everything else follows. The Supply Builder sizes the whole program in one order.

The two conversations that belong with a physician

1. HRT. This program complements hormone therapy decisions; it does not make them. Labs, family history, and the estrogen conversation belong with a practitioner who engages — here's how to run that conversation.
2. The hard line stands: pregnant, trying, or nursing — none of this, full stop, and yes, perimenopause pregnancies happen. The Women & Peptides guide carries the complete picture.

Research protocols, not a prescription — talk to a physician before touching anything.

Compounds in this program