Stacks / Gut & Inflammation
The Gut Program
The gut-repair protocol — built around the compound that was literally discovered in stomach protection, the inflammation-calming layer, and the systemic build on top.
Half the people who end up in the peptide world arrive through a gut problem — the bloat that never resolves, the NSAID-wrecked stomach, the IBS-shaped thing no scan explains, the training gut that ruins weight cuts. There's a reason this category works: BPC-157, the most famous peptide in the space, was discovered in gastric juice — "Body Protection Compound" — and its deepest research lane has always been the gut lining, not the tendons that made it famous.
The Foundation — the lining first
- BPC-157 + TB-500 (blend) — 500 mcg daily. BPC's home turf: gastric and intestinal lining protection and repair, with the systemic tissue leg riding along.
- KPV — 400 mcg daily. The anti-inflammatory specialist — its research lane is inflammatory bowel conditions specifically: the calm-the-fire half of the pairing, while BPC rebuilds.
- NAD+ — 100 mg daily. Gut epithelium is one of the fastest-regenerating tissues you own — regeneration at that pace is an energy bill.
The Gut-Specific Layer
- Glutathione — 400 mg, 3× weekly. Gut inflammation generates oxidative load (and a stressed liver sits right downstream); the antioxidant leg.
- DSIP — 200 mcg pre-bed. The gut-sleep axis is real and bidirectional — bad nights inflame guts, bad guts wreck nights. This breaks the loop from the sleep side.
The Complete Optimal Build
- Thymosin Alpha-1 — 1.6 mg, 2× weekly. Around 70% of your immune system lives in the gut wall; TA-1 is the immune-balancing leg for the version of gut trouble that's really an immune-regulation problem.
The full program at a glance
| Layer | Compound | How it's run |
|---|---|---|
| Foundation | BPC-157/TB-500 blend | 500 mcg daily |
| Foundation | KPV | 400 mcg daily |
| Foundation | NAD+ | 100 mg daily |
| Gut layer | Glutathione | 400 mg 3×/week |
| Gut layer | DSIP | 200 mcg pre-bed |
| Optimal | Thymosin Alpha-1 | 1.6 mg 2×/week |
The honest timeline: gut lining turns over fast (days), but calming an inflamed system is a 6–8 week project minimum. The Supply Builder sizes the full window in one order.
The part no vial fixes
The research protocols above sit on top of the boring layer, not instead of it: identify the trigger foods, respect the NSAID problem (grapplers especially — this is half of why the Weight-Cut protocol exists), and take anything persistent to a gastroenterologist. Blood in stool, unexplained weight loss, or fever is a doctor visit, not a protocol.
For the women reading this
Gut and immune biology here run identically — Standard tier as written. Worth knowing: IBS-pattern gut trouble skews female in the literature, and the gut-hormone crosstalk is real — the Women & Peptides guide covers where cycles interact with gut symptoms.
Research protocols, not a prescription — talk to a physician before touching anything.
Compounds in this program
BPC-157
The most-discussed recovery peptide — studied for tendon, ligament, muscle, and gut repair. The usual first compound for anyone training hard with nagging injuries.
TB-500
BPC-157's usual partner — studied for flexibility, tissue repair, and reducing inflammation across the whole body rather than one site.
KPV
A three-amino-acid fragment of a natural anti-inflammatory hormone — studied for gut inflammation, skin conditions, and calming an over-active immune response.
NAD+
Not technically a peptide — the cellular energy coenzyme itself, injected to restore levels that fall ~50% between youth and middle age. The longevity-circuit staple.
Glutathione
The body's own master antioxidant — a tripeptide on every IV-therapy and med-spa menu, studied for detoxification, recovery, and oxidative stress.
Thymosin Alpha-1
The immune-modulation peptide — an approved drug in 30+ countries that trains the immune system's response rather than suppressing or overstimulating it.
DSIP
The sleep peptide — studied since the 1970s for deepening slow-wave sleep, which is where every other kind of recovery actually happens.