Peptide Library / Men's Health
Kisspeptin-10
Also known as: Metastin fragment
The upstream hormone switch — the signal that tells your brain to run the entire testosterone production line. Studied for natural hormonal support and desire.
| Typical research dose | 100–200 mcg |
|---|---|
| Frequency | 2–3× weekly (protocols vary widely) |
| Route | Subcutaneous injection |
| Cycle length | 4–8 weeks |
Figures reflect protocols commonly reported in the research community — not a prescription or a recommendation.
What it is
Kisspeptin sits at the very top of the male hormonal cascade: it signals the hypothalamus to release GnRH, which tells the pituitary to release LH, which tells the testes to make testosterone. It's the ignition switch for the whole axis — which is why it's studied as a way to stimulate natural production rather than replace it (the fundamental difference from TRT, which shuts the native line down).
What the research looks at
- LH and testosterone response — human studies show kisspeptin infusion reliably raises LH pulses and downstream testosterone in men.
- Fertility preservation — because it works the natural axis, research interest centers on hormonal support that doesn't suppress sperm production.
- Desire and behavior — human fMRI studies showed enhanced limbic response to romantic stimuli — a brain-level desire effect distinct from PT-141's.
- What's missing — established protocols; this is genuinely early-stage territory and the pharmacology (short half-life, receptor desensitization at continuous exposure) makes dosing non-obvious.
How protocols are commonly structured
Research-community protocols are young and vary: 100–200 mcg subcutaneous, two to three times weekly is the common shape, deliberately intermittent — the axis responds to pulses, and continuous stimulation desensitizes the receptor (the opposite of the goal). Anyone considering the hormonal lane seriously should be getting labs, full stop — this is the one category where numbers exist to check.
Reconstitution & storage
Lyophilized powder; bacteriostatic-water reconstitution (calculator), refrigerate after mixing.
Research protocols, not a prescription — talk to a physician before touching anything.